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TLDR: Chronic fatigue is a persistent and overwhelming sense of tiredness or lack of energy that does not improve with rest. It can be a symptom of various underlying conditions, including chronic fatigue syndrome (CFS), infections, autoimmune diseases, or mental health disorders. Chronic fatigue often affects daily functioning, productivity, and overall quality of life, requiring careful evaluation to determine its root cause.

https://en.wikipedia.org/wiki/Fatigue_(medical)

Chronic fatigue differs from ordinary tiredness as it is more severe, long-lasting, and often accompanied by other symptoms such as difficulty concentrating, muscle pain, or unrefreshing sleep. In cases like chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), the condition may persist for months or years without a clear cause. Diagnosis involves ruling out other potential conditions, such as anemia, hypothyroidism, or depression, through medical history, physical exams, and laboratory tests.

https://www.cdc.gov/me-cfs/index.html

Management of chronic fatigue depends on the underlying cause and may include lifestyle changes, medication, or therapy. For example, graded exercise therapy and cognitive-behavioral therapy are sometimes recommended for CFS/ME. Nutritional support, stress management, and adequate sleep hygiene can also play significant roles in improving symptoms. Chronic fatigue is a complex condition that requires a multidisciplinary approach to treatment and long-term management.

https://www.mayoclinic.org/diseases-conditions/chronic-fatigue-syndrome/symptoms-causes/syc-20360490